Jose Mourinho has left Manchester United with "immediate effect", the club has confirmed.
It comes after Manchester United's 3-1 defeat against Liverpool on Sunday.
The 55-year-old won three trophies during his first season at Old Trafford, but had come under increasing pressure this year with the team languishing in sixth place, 19 points behind their Merseyside rivals.
In recent months, the former Chelsea boss had fallen out with marquee signing and French World Cup winner Paul Pogba.
A statement from Manchester United on Tuesday read: "The club would like to thank Jose for his work during his time at Manchester United and to wish him success in the future.
"A new caretaker manager will be appointed until the end of the current season, while the club conducts a thorough recruitment process for a new, full-time manager."
Mourinho had enjoyed considerable success at Porto, Chelsea, Inter Milan and Real Madrid before replacing Louis van Gaal at Old Trafford in 2016.
In his second season in charge, he guided United to second place in the Premier League behind rivals Manchester City.
And despite progression to the Champions League knockout stages this season, Mourinho had found himself under increasing pressure for his perceived style of negative football.
Fallings-out with a number of his players was met with criticism from ex-pros such as Paul Scholes.
Mourinho's final game in charge came on Sunday, as league leaders Liverpool breezed past Manchester United 3-1 courtesy of goals from Sadio Mane and Xherdan Shaqiri.
